Ongoing Studies

Advancing the science of health and nutrition

We are supporting active research projects at
cutting-edge academic centers worldwide.
Click on the product name below to learn more about each study

ALPHA-GPC Alpha GPC on Muscle Performance University of Montreal
ALPHA-GPC Alpha GPC on Cognition University of Montreal
ALPHA LIPOIC ACID Lipoic Acid for Treatment of Progressive Multiple Sclerosis Oregon Health Science University
ALPHA LIPOIC ACID Comparing the gastrointestinal tolerability and absorption of racemic lipoic acid and R-lipoic acid in progressive multiple sclerosis: a cross-over trial Oregon Health Science University
ALPHA LIPOIC ACID Therapeutic evaluation of alpha-lipoic acid for geographic atrophy. University of Pennsylvania
CURCUMASORB VITAMIN D3 5,000 IU O.N.E. OMEGA Correlative Analysis of the Genomics of Vitamin D, Omega-3 Fatty Acid Intake and Turmeric Curcumin in Men Managed with Active Surveillance of Prostate Cancer. Cleveland Clinic
EPA Antidepressant augmentation with EPA for major depression in patients with CHD. Washington University School of Medicine
FOLIC ACID AND METHYLCOBALAMIN Arsenic and B vitamins in Children Columbia University
GINGER Effect of ginger supplement in alleviating anemia in postpartum women. North Carolina Central University and Center for Family Health Allegiance Health
IP-6 Phytic acid for treating alzheimer’s disease: a randomized trial. University of Florida
MOTILPRO® Small intestinal bacterial overgrowth-preventing recurrence with MotilPro® Stephen F. Austin State University
OMEGA-3 Benefits of omega-3 fatty acids in maintaining/stimulating skeletal muscle turnover in older women. University of Nottingham
PREGNENOLONE Randomized Controlled Pilot Trial of Pregnenolone in Autism Department of Psychiatry & Behavioral Sciences, Stanford University
PROBIOTICS Investigating small intestine bacterial overgrowth in children. Jeroen Bosch Hospital
VITAMIN D Multidisciplinary consortium from 16 European countries focused on designing and developing a food pyramid and dietary guidelines for those over 65 years old. (NU-AGE). Wageningen University
VITAMIN D Effects of maternal vitamin D supplementation on markers of vitamin D status and related infant and maternal health outcomes in southern Ethiopia. Oklahoma State University
VITAMIN D A randomized, comparative study of the effects of winter supplementation with ultraviolet light versus oral vitamin D to assess the effects on immune tolerance. University of Aberdeen
VITAMIN D The effects of oral vitamin D3 on markers of immune system regulation: a randomized controlled trial. University of Aberdeen
ZINC GLUCONATE The Effect Of Oral Zinc Supplementation For The Treatment Of Psoriasis. Park Avenue Dermatology, Orange Park Medical Center, Orange Park Florida
Independent studies are conducted by independent, academic researchers. Atrium Innovations has no influence on study results. Study titles are provided for informational purposes only and are not intended as product claims or to imply a positive outcome.

Age-Related Macular Degeneration is a condition which causes gradual worsening of vision during the aging process. Approximately 10 million Americans are affected by ARMD, which may be caused by a variety of factors including genetics, lifestyle, and oxidative stress. This placebo-controlled study investigates the role of oxidative stress in ARMD and the potential of Alpha Lipoic Acid (ALA) in preventing or slowing progression of ARMD.×





This placebo-controlled study investigates co-administration of antidepressants with the omega-3 fatty acid eicosapentaenoic acid (EPA) in patients with coronary heart disease (CHD). Some studies have shown that depression may increase morbidity risk in patients with stable CHD and in patients recovering from acute coronary events. A large body of evidence surrounds the role of omega-3 fatty acids in mood support, and some preliminary studies have investigated the role of fatty acids in improving antidepressant efficacy. This study will examine depression ratings as well as cardiovascular risk markers throughout the trial. ×


Arsenic-contaminated drinking water can be found in areas of South and East Asia. Exposure to arsenic-contaminated water may cause toxicity and compromised health states in these populations. The folate cycle is involved in the methylation of arsenic, helping to eliminate arsenic levels from the body. Folate, a form of vitamin B, can be found in many leafy vegetables, citrus fruits, and whole grains. This study investigates the efficacy of folate supplementation and other co-factors in enhancing methylation and urinary excretion of arsenic in an arsenic-exposed population. ×


Anemia is characterized as a decrease in red blood cells or hemoglobin and is especially prevalent in women. Postpartum anemia is often caused by blood loss during delivery, and has been linked to postpartum depression, fatigue, and decreased lactation. This study investigates the potential of ginger to help improve anemia status in postpartum women and will measure hemoglobin and hematocrit levels throughout the trial. ×


Phytic Acid, known as inositol hexakisphosphate (IP-6) is a phytochemical with antioxidant properties. Phytic acid is found in food grains and is instrumental in many molecular signaling processes. Some studies have noted higher than normal levels of iron and copper in neurological diseases such as Alzheimer’s disease (AD), which may contribute to oxidative and inflammatory stress. This study aims to compare standard mental function tests, safety, and inflammatory and oxidative markers in patients with AD receiving IP-6 versus placebo. ×


Loss of skeletal muscle mass, quality, and strength is often associated with aging. Studies have shown the loss of muscle mass dramatically increases between the age range of 70-75 years and 85 and older. This study uses a proprietary method to define and assess sarcopenia, and will examine the effects of omega-3 supplementation on measures of muscle status in elderly participants. ×


Polyphenols are a structural class of chemicals found in a variety of phytochemical-bearing plants. These compounds, which are responsible for the coloring of some fruits, flowers, and vegetables, have also been reported to potentiate antimicrobial, antiviral, and antioxidant effects. A growing body of evidence suggests that the consumption of polyphenols may also modulate insulin response and reduce fat cell formation. In this study, healthy yet overweight individuals are being administered a polyphenol combination and assessed for fat oxidation and insulin sensitivity during fasting and after a high fat meal. Body composition is being assessed throughout the study. ×


Small Intestine Bacterial Overgrowth (SIBO) has been associated with the development of other conditions, such as diabetes mellitus and scleroderma. Live beneficial microorganisms known as probiotics are crucial to the health of the digestive tract and immune system. In maintaining a proper balance of probiotic organisms, it has been suggested that the overgrowth of harmful bacterial overgrowth may be attenuated. This study investigates probiotic use in alleviating SIBO in children ages 8-18 presenting with clinical symptoms of functional bowel disorders and SIBO. Subjects will be administered probiotics or placebo and will be assessed for pain intensity and alterations in the gut microflora. ×


Saw palmetto is an extract from the fruit of the Serenoa repens, the American dwarf palm. Saw palmetto has been used for over 200 years in various conditions. It is rich in fatty acids and phytosterols, and has been commonly used in the reduction of prostate inflammation and in urogenital indications. Lower urinary tract symptoms (LUTS) affect from 75-80% of men undergoing radiation therapy (RT) for prostate cancer. Saw palmetto is commonly used to alleviate these symptoms. This investigation examines the feasibility, safety, and efficacy of varying doses of saw palmetto in men experiencing LUTS while undergoing radiation therapy for prostate cancer. ×


An increasing body of literature suggests inadequate vitamin D as a risk factor for vascular dysfunction, metabolic syndrome, and cardiovascular disease later in life. This study will assess vitamin D deficiency in obese and overweight children and the effects of vitamin D3 supplementation on vascular function, adipokines, inflammatory markers, and metabolic risk. ×


Low vitamin D levels have repeatedly been linked to chronic pain and low pain tolerance. This pilot study will assess pain levels in patients with chronic low back pain. Pain scores and functional status will be assessed throughout the duration of this trial. ×


NU-AGE is a randomized single-blind controlled multi-center dietary intervention trial focused on redefining the dietary guidelines for European individuals over the age of 65. This study, funded by the European Commission, will redesign the food pyramid for this age group, emphasizing nutrient-density, water, dietary fiber, vitamin D, and vitamin B12. This study includes 31 partners from 17 European countries. Vitamin D3 tablets were contributed to this initiative. For more information see ×


A recent study characterized over 77% of Americans as Vitamin D deficient, and this area is of particular growing interest for athletes. Individuals with spinal cord injury are at increased risk of vitamin D deficiency due to poor diet and decreased exposure to sunlight and outdoor activity, and these low serum levels may place the individual at further risk for osteoporosis and fracture. This study aims to assess the prevalence of vitamin D deficiency in athletes with spinal cord injury and evaluate the effectiveness of vitamin D3 supplementation on 25(OH)D status, muscle function, and injury occurrence. ×


It has been generally accepted that vitamin D status is linked to sunlight exposure, however, geographic location as a predictor for vitamin D status does not account for habits of dress and lack of fortified foods. This study in Ethiopia aims to further investigate data showing a high prevalence of women of maternal age with low 25(OH)D serum levels. Vitamin D deficiency is also known to be a cause of osteomalacia (“rickets”) which also has a high prevalence in this area. This study will administer vitamin D3 to postpartum women and assess plasma and breast milk markers of vitamin D, vitamin D status in women and infants, and incidence of rickets. ×


Vitamin D synthesis can be triggered in humans through sunlight exposure to UVB rays. In winter months, especially in areas of higher latitude, sunlight exposure may be limited and can lead to decreased vitamin D status. This study aims to compare the effects of ultraviolet light in doses similar to normal summer exposure to oral cholecalciferol supplementation in maintaining 25(OH)D status and immune status. ×


This placebo-controlled study, undertaken during winter at a high northern latitude with decreased sun exposure, will test whether oral daily vitamin D3 at current nutritional recommendations affects markers of immune system regulation, including T-cell and cytokine expression. ×

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