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Archive for category: Research

Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid.

Allaire J, Harris W, Vors C, et al. PLEFA. 2017.

 

The increase in omega-3 index was greater with supplemental DHA than EPA. The omega-3 index has been inversely associated with the risk of coronary heart disease and coronary mortality.

 

Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial

Peters BA, Hall MN, Liu X, et al. J Nutr. 2016.

 

Creatine + folic acid supplementation decreased plasma guanidinoacetate and total homocystiene levels.

Folic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial

Peters BA, Hall MN, Liu X, et al. Envir Health Perspect. 2016.

 

PUFA showed no benefit over placebo in NASH patients with diabetes in terms of liver enzymes, body weight or body composition, and did not show a positive impact on insulin response.

Double blind randomized placebo controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis

Dasarathy S, Dasarathy J, Khiyami A, et al. J Clin Gastroenterol. 2015.

 

PUFA showed no benefit over placebo in NASH patients with diabetes in terms of liver enzymes, body weight or body composition, and did not show a positive impact on insulin response.

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 weeks increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial

Most J, Timmers S, Warnke I, et al. Am J Clin Nutr. 2016

 

EGCG+RES supplementation did not affect the fasting plasma metabolic profile. Although whole-body fat mass was not affected, visceral adipose tissue mass tended to decrease after the intervention compared with placebo.

Randomized, crossover, head-to-head comparison of EPA and DHA supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA Study

Allaire J, Couture P, Leclerc M, et al. Am J Clin Nutr. 2016.

 

DHA is more effective than EPA in modulating specific markers of inflammation as well as blood lipids.